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Pluvicto Radiopharmaceutical Therapy

Pluvicto Radiopharmaceutical Therapy

A targeted, PSA-based therapy for advanced prostate cancer, delivering precision treatment to extend both survival and quality of life, right here in Boca Raton.

Expert Cancer Care You Can Trust

At Lynn Cancer Institute, we are among the first in South Florida to offer Pluvicto, an FDA-approved radioligand therapy for PSMA-positive metastatic castration-resistant prostate cancer (mCRPC). Delivered via infusion, this precision therapy directly targets cancer cells while minimizing damage to normal tissue. According to Dr. Michael Kasper, it can extend survival and preserve quality of life for patients with advanced prostate cancer.

Expert Cancer Care You Can Trust

Our Approach

We begin with a PSMA PET scan to confirm eligibility. Pluvicto is then delivered in a series of monthly infusions, typically spanning several months, under close monitoring by our interdisciplinary oncology team. Treatment is coordinated carefully to ensure both efficacy and patient comfort.

Our Approach

What Is Pluvicto?

Pluvicto (lutetium-177 vipivotide tetraxetan) is a radiopharmaceutical designed to bind to PSMA proteins on prostate cancer cells. Once attached, the radioactive component delivers localized radiation, causing targeted cell death with minimal impact on healthy tissue.

When Is It Recommended?

Pluvicto is indicated for patients with:

PSMA-positive mCRPC who have already received androgen receptor pathway inhibitors and are appropriate to delay or have received taxane chemotherapy.

Recent FDA updates now also allow its use earlier in the treatment sequence, for patients who are still hormone-sensitive but PSMA-positive.

Benefits and Risks

Benefits
  • Delivers radiation directly to cancer cells expressing PSMA
  • Reduces progression risk by 59% compared to alternative hormone therapies
  • Targets systemic disease with limited exposure to healthy tissue
  • Typically well-tolerated, enabling treatment continuity
Risks

Possible side effects include fatigue, nausea, dry mouth, anemia, and appetite loss. Some patients may also experience dry mouth due to PSMA expression in salivary glands.

What to Expect

  • Before therapy, a PSMA PET scan is required to confirm eligibility. Regular lab tests monitor blood counts and organ function. Counseling is provided on safety measures post-treatment, such as hydration and limiting close contact, to minimize radiation exposure to household members.

  • Each treatment involves an intravenous infusion typically administered as an outpatient. The radioligand targets PSMA-expressing tumor sites while you remain under observation for a few hours.

  • Patients generally return home the same day. Follow-up includes routine scans and lab tests to evaluate response and manage side effects. Most continue regular activities with minimal interruption.

Meet Our Specialists

Our specialists in prostate cancer treatment are trained in using targeted therapies like Pluvicto. At LCI, your care is guided by a team of board-certified experts who understand both the science and the emotional support needed to navigate treatment.

Expert Care Close to Home

Lynn Cancer Institute | Boca Raton
Open until 5 p.m.

Lynn Cancer Institute | Boca Raton

701 NW 13 St., Boca Raton, FL 33486

Frequently Asked Questions

  • It binds to PSMA on prostate cancer cells, delivering targeted radiation directly to those cells.

  • Typically via infusion every six weeks, for up to six cycles.

  • Patients with PSMA-positive mCRPC who have previously undergone hormone therapy, and now earlier-stage disease due to expanded FDA approval.

  • Mainly fatigue, nausea, dry mouth, anemia, and decreased appetite.

News & Podcasts

News

View All
Innovative Prostate Cancer Drug Offered at Lynn Cancer Institute December 26, 2024

A drug that “substantially helps” extend survival for patients with incurable late-stage prostate cancer is available in Palm Beach County exclusively at the Eugene M. & Christine E. Lynn Cancer...

New Drug Extends Survival for Late-Stage Prostate Cancer Patients February 28, 2024

Baptist Health Miami Cancer Institute is among the first cancer centers in the region to offer an innovative radiopharmaceutical therapy that can extend survival and increase quality of life for...

Prostate Cancer: Know the Facts October 1, 2013

T.V. personality Dr. Drew Pinsky calls prostate cancer a “stealth disease” because it rarely makes its presence felt, especially in the early stages, and it can simmer for years.Pinsky would know. He...

Podcasts

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The Conversation Men Need to Have — and Why It Starts Now June 20, 2025
Championing Men's Health: A Conversation with Alonzo Mourning November 20, 2024
Prostate Cancer Awareness: Screening & Treatment September 15, 2020

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